Overview matrix (left/top pane)
This matrix gives an overview of the significant associations on a genome- and metabolome-wide scale.
For any combination of locus/metabotype and metabolite, it shows the p-value and beta estimate for the genetic variant with the strongest association signal at a given locus/metabotype.
You can adjust the matrix (filter and sort) in the "Settings".
Click on any cell in the matrix to get annotations for the selected locus and metabolite in the right/bottom pane.
Locus annotations (right/bottom pane)
Select a locus of interest using the dropdown menu in the header or by clicking on a cell in the overview matrix.
The locus matrix shows all indepentenly associated variants and their metabotype membership within a locus.
Use this matrix select associations for which summary statistics, annotations and plots should be displayed. By default, all significantly associated associations of a locus and/or metabotype are selected.
Plot legend
| Columns |
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Metabolic pathway (abbrv.), metabolites |
| Rows |
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Overview matrix: Candidate causal gene, locus/metabotype
Locus matrix: lead SNP, candidate causal gene, metabotype
|
| Cells |
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Number: ⌈-log10(p)⌉ of the (lead) SNP.
Color: effect size and direction, ranging from -1 (blue) to +1 (red).
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